Rockwell will deliver a 30-storey landmark building on the site, which has been derelict for over a decade, at the gateway to Canary Wharf and next to Westferry DLR station.
The hotel will feature 400 rooms including a ground floor restaurant, café and bar.
The development has been designed by leading UK architects Simpson Haugh and Partners, the practice responsible for One Blackfriars and Circus West Village at Battersea Power Station.
Donal Mulryan, founder of Rockwell, said: “Our vision for 82 West India Dock Road will breathe new life into a neglected site that has been derelict for many years. This inspiring new building includes a hotel that will bring new jobs and business to the local area, in addition to much needed new homes for the local community in an inspiring new building.
“We are dedicated to delivering this exciting, high-quality development and look forward to turning this site into a place that locals can be proud of.”
Construction is due to start on the site in summer 2019.